Global markets and competition have forced companies to operate in a physically distributed environment to take the advantage of benefits of strategic alliances between partnering firms. Furthermore, global operations asked for suitable Enterprise Information Systems (EIS) such as Enterprise Resource Planning (ERP) and E-Commerce (EC) for the integration of extended enterprises along the supply chain to achieve flexibility and responsiveness. Companies all over the world spend billions of dollars in the design and implementation of EIS in particular ERP systems such as Oracle, Peoplesoft, SAP, JD Edwards, and BAAN intending to achieve an integrated global supply chain. Inter-organizational information systems play a major role in improving communication and integration between partnering firms to achieve an integrated global supply chain. Nowadays, digital transformation asked for new business models and a change in the design and development of EIS with increased relevance of mobility, virtualization, and the use of analytics for creating and capturing value from big data. Also, open innovation and crowdsourcing have questioned the way companies engage with both their outer and inner context and, together with the further adoption of robotics and artificial intelligence (AI), are asking for a new breed of EIS to support their enactment. In summary, there is a growing demand for research and applications that will provide insights into issues, challenges, and solutions related to the successful applications and management aspects of EIS, and this journal aims to be the venue for researchers interested in their investigation, understanding, and development.