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Drug-Nanoparticle Composites: A Predictive Model for Mass Loading

Drug-Nanoparticle Composites: A Predictive Model for Mass Loading

Natalia Sizochenko, Jerzy Leszczynski
Copyright: © 2017 |Volume: 2 |Issue: 1 |Pages: 10
ISSN: 2379-7452|EISSN: 2379-7444|EISBN13: 9781522515975|DOI: 10.4018/JNN.2017010101
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MLA

Sizochenko, Natalia, and Jerzy Leszczynski. "Drug-Nanoparticle Composites: A Predictive Model for Mass Loading." JNN vol.2, no.1 2017: pp.1-10. http://doi.org/10.4018/JNN.2017010101

APA

Sizochenko, N. & Leszczynski, J. (2017). Drug-Nanoparticle Composites: A Predictive Model for Mass Loading. Journal of Nanotoxicology and Nanomedicine (JNN), 2(1), 1-10. http://doi.org/10.4018/JNN.2017010101

Chicago

Sizochenko, Natalia, and Jerzy Leszczynski. "Drug-Nanoparticle Composites: A Predictive Model for Mass Loading," Journal of Nanotoxicology and Nanomedicine (JNN) 2, no.1: 1-10. http://doi.org/10.4018/JNN.2017010101

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Abstract

Polymeric nanoparticles represent attractive targets for the controlled delivery of therapeutic drugs. Drug-nanoparticle conjugates are convenient targets to enhance solubility and membrane permeability of drugs, prolong circulation time and minimize non-specific uptake. The behavior of drugs-loaded nanoparticles is governed by various factors. Understanding of these effects is very important for design of drug-nanoparticle systems, that could be suitable for treating the particular diseases. The aim of the current study is a complementary molecular docking followed by quantitative structure-activity relationships modeling for drugs payload on polymeric nanoparticles. Twenty-one approved drugs were considered. Docking of drugs was performed towards a simplified polymeric surface. Binding energies agreed well with the observed mass loading. Quantitative structure-activity relationships model supported this data. Effects of electronegativity and hydrophobicity were discussed. Developed model may contribute to the development of other useful nano-sized polymeric drug carriers to deliver a spectrum of therapeutic and imaging agents for medical purposes.

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